AdSkate is an AI-powered creative intelligence platform that helps brands analyze and optimize advertising performance. Founded by industry veterans, AdSkate bridges creativity and data to help brands optimize ad performance 5x faster while increasing return on ad spend (ROAS) by up to 45%.

Advanced Optronics is a medical device company co-founded by engineers from Carnegie Mellon University developing flexible, biocompatible micro-scale sensor systems for real-time AI guidance in surgery. Founded in 2021 to commercialize CMU research, the company has received NSF grant support.

Agot AI is a computer vision platform company serving enterprise foodservice and fast-food operators, using AI to improve order accuracy and operational efficiency. The company raised a $10 million funding round in September 2021 to expand its technology in the restaurant industry.

Behaivior AI is a Pittsburgh-based digital health company making mental health and addiction recovery more equitably accessible using AI, behavioral health technology, and wearables. Its platform uses advanced pattern recognition to provide real-time support for individuals in recovery and their care providers.

BlastPoint is a B2B provider of AI-powered customer intelligence and analytics solutions headquartered in Pittsburgh, Pennsylvania. The company provides AI solutions for customer growth targeting utility and financial services industries.

Carbonara, Inc. is an AI-powered restaurant waitlist and reservation management platform that helps non-reservation restaurants manage queues and online bookings more efficiently. The company is headquartered in Pittsburgh, Pennsylvania, and was founded in 2020 by CEO Luke Panza.

Carnegie Speech Company is a developer of software for assessing and teaching spoken language skills, using patented speech recognition and AI technology. It provides speech training solutions to help non-native speakers improve English clarity and comprehension.

Clean Plate Innovations (CPI) is an AI-enabled food waste tracking cleantech startup founded by Nolan Sulpizio. The company's CPIsight platform helps large-scale dining operators visualize exactly what food is wasted, why, and how to fix it, targeting a 15–30% reduction in food costs for institutional dining programs.

Crystal is a personality data platform that reveals the natural personality of B2B prospects, helping sales teams communicate more effectively. The platform combines multiple assessment types with AI predictions to build accurate personality profiles. Headquartered in Nashville, TN, Crystal is widely used by sales and recruiting teams.

D.Sole is a health technology company developing a smart insole system that uses multimodal sensors and machine learning for the early detection and monitoring of diabetic foot complications such as ulcers. The platform integrates with a clinical decision support system to advance lifelong mobility for patients with diabetes.

Equa Health is a science-backed mindfulness training platform designed to change how people respond to stress in real time. Its system draws on research from the Health and Human Performance Lab at Carnegie Mellon, offering practical skill-building rather than temporary relief. The platform is available at equahealth.io.

Hardly offers AI-powered career tools that enable collaboration between job center staff and jobseekers, streamlining job applications and career assessments. A Techstars '25 and AlphaLab '25 graduate, the company focuses on workforce development technology.

LifeWhere was a predictive maintenance company that used machine learning and analytics to predict potential failures in critical home appliances such as water heaters and furnaces via cloud-based analytics and machine sensors. The company was acquired by Resideo in 2019, which integrated its technology into the Pro-IQ LifeWhere remote monitoring solution.

MedRespond is an online healthcare communications company that combines artificial intelligence, search, and streaming media to enable conversational patient engagement. The company pioneers cloud-based tools that make healthcare communications as simple and powerful as a conversation.

Mobile Aspects, Inc. is a Pittsburgh, PA-based healthcare technology company that provides RFID, AI, and IoT solutions to help hospitals automate inventory tracking, specimen management, and surgical workflows. The company offers real-time visibility into supplies and scopes for leading healthcare organizations.

Motoria is an AI-powered search platform for new and used vehicles, enabling users to search millions of cars using natural language to find their ideal vehicle. The company applies artificial intelligence to simplify the automotive search experience for consumers.

Naima Health is a digital health company that develops tools using behavioral decision science, clinical science, and machine learning to engage patients in their clinical care. The company's platform is designed to help patients more actively participate in managing their own health outcomes.

OctaPulse is an aquaculture technology company (YC W26) that develops AI-powered computer vision systems to automate quality inspection in fish hatcheries. Its platform automates juvenile fish grading, deformity detection, and broodstock phenotyping to improve efficiency and outcomes for fish farms.