Knapsack is a Portland, Oregon–based enterprise software company providing infrastructure that connects design and code into a real-time system of record. Its digital production platform enables enterprise teams to build, govern, and deliver digital products at scale, integrating with tools like Figma and Git. The company raised $10 million in funding as of October 2025.

CleanHaus is an AI-powered property care and operations platform built for the short-term rental community, serving hosts, cleaners, and contractors. It automates cleaning coordination and scheduling to reduce operational stress and help deliver five-star guest experiences. The platform is accessible at clean.haus.

Play Cubed is a Los Angeles-based software company, also operating as Unvault.AI, with a team experienced in frontier technology. It was founded by Randy Saaf, Octavio Herrera, Fazri Zubair, and Noah Edelman. The company is a small, early-stage firm in the software development space.

Absci is a clinical-stage biopharmaceutical company headquartered in Vancouver, Washington that uses generative AI to design and develop differentiated drug therapeutics. Founded in 2011, Absci is publicly traded on Nasdaq (ABSI).

Acolyte Health is a patient engagement company that delivers personalized instructions, connections, and education to improve health outcomes. The company provides solutions that support patients through their care journey with tailored communications and resources.

ActionSprout is a Seattle-based company that built a platform helping nonprofits maximize their Facebook presence through custom action tools such as donation collection, petition signing, and supporter engagement beyond standard likes and shares. Founded around 2012, the company focused on enabling nonprofits to convert social media audiences into active participants.

Agility Robotics is a Salem, Oregon–based humanoid robotics company whose robots are deployed in manufacturing, distribution, and logistics environments. The company is set to go public in a deal valuing it at approximately $2.5 billion, according to published reports.

AheadComputing is a Beaverton, Oregon-based semiconductor company building high-performance RISC-V processors for AI, cloud, and edge computing. The company was founded by Intel CPU architects with over 100 years of combined experience in microprocessor design.

AiStrike is a cybersecurity company offering a Composite AI platform that automates and unifies every stage of the security operations center (SOC) lifecycle. The platform deploys agentic AI to help organizations reduce alert noise, accelerate incident response, and modernize security operations without the cost and complexity of traditional managed detection and response.

AppThwack was a Portland-based cloud testing startup that provided automated mobile app testing on real physical devices, supporting Android, iOS, and web apps across more than 200 phones and tablets. The company partnered with In-Q-Tel (IQT) to expand its app testing technology and integrated with CI tools like Jenkins. AppThwack was acquired by Amazon and became part of AWS Device Farm.

Apptio, headquartered in Bellevue, Washington, provides Technology Business Management (TBM) software that helps organizations translate technology investments into business value and optimize IT spend. IBM acquired Apptio in August 2023 for $4.6 billion; the company now operates as IBM Apptio.

Augment Code is an AI-powered coding assistant built for professional software engineers and large codebases. Its Cosmos platform runs software agents at scale, providing context, tools, and feedback loops to improve development workflows. The company positions itself as purpose-built for enterprise-grade software development.

Backpack is a digital payments platform built specifically for higher education, replacing check-based workflows with electronic payment infrastructure. It handles 529 college savings plan payments, scholarships, and third-party payments for universities via API-driven payment gateways.

Bacon is a flexible work marketplace that connects gig workers with local companies for on-demand hourly shifts. Workers find and book single shifts through the Bacon app and receive quick payment upon completion. The platform serves both job seekers looking for flexible work and businesses needing on-demand hourly labor.

Bigleaf Networks is an SD-WAN and cloud networking company that provides a managed network optimization service for businesses, using a holistic wireless-first approach to boost application responsiveness and internet performance over commodity broadband circuits such as cable and DSL. The company markets its service under the Bigleaf Cloud Connect brand.

Biomotum is a medical device company that builds wearable robotic rehabilitation products designed to support clinicians in improving walking function for individuals with neurologic impairments. Its Spark device is a powered exoskeleton intended for rehabilitation and personal use by individuals with gait impairments.

Birch Biosciences is a Portland, Oregon biotechnology company that develops novel plastic recycling technologies using generative AI and advanced enzyme engineering to bring plastics into the circular economy. Founded in 2021 by Johan Kers, the company is a Y Combinator-backed startup.

Bitesize is an AI-powered follow-up automation platform for automotive dealership CRMs, enabling lead reactivation and consumer engagement at scale. The company helps car dealerships generate and close leads by managing interactions without requiring a CRM switch. Bitesize also offers a broader conversation management platform for brands to communicate with consumers one-on-one at scale.

Blendoor is a diversity analytics and inclusive recruiting software company that mitigates unconscious bias in hiring. Its platform sources job candidates from hundreds of strategic partners and provides diversity and inclusion analytics, including a BlendScore rating for companies. Founded by Stephanie Lampkin, Blendoor enables companies to attract and retain diverse talent.