Absci is a clinical-stage biopharmaceutical company headquartered in Vancouver, Washington that uses generative AI to design and develop differentiated drug therapeutics. Founded in 2011, Absci is publicly traded on Nasdaq (ABSI).

Biomotum is a medical device company that builds wearable robotic rehabilitation products designed to support clinicians in improving walking function for individuals with neurologic impairments. Its Spark device is a powered exoskeleton intended for rehabilitation and personal use by individuals with gait impairments.

Caravel Bio is a Portland, Oregon–based synthetic biology startup building a novel protein evolution platform that creates proteins exceeding nature's bounds to serve as new protein machines. The company targets applications in critical minerals, carbon capture, and industrial processes using cell-free protein engineering methods.

Cascade Prodrug is an oncology-focused biotechnology company developing a novel class of hypoxia-activated prodrug therapies that target diseases rooted in oxygen deprivation, including solid tumors and wet AMD. Its lead program, CPD100, is designed to selectively activate in hypoxic tissue. The company is led by seasoned pharmaceutical and biotech executives.

ClearFlow, Inc. is a medical device company headquartered in Irvine, California, focused on post-surgical chest tube clearance. Its flagship product, the PleuraFlow Active Clearance Technology system, is designed to maintain chest tube patency following cardiac and thoracic surgery. The company holds a comprehensive portfolio of U.S. and international patents covering its clearance technology.

CytoImage is a Portland, Oregon-based biotechnology company founded in 2020 that develops imaging diagnostic technology for cancer detection. The company's platform provides rapid and precise assessment of phenotypic functional response to identify cancer cells, with its last known funding round in July 2021.

Célage Bioscience is a direct-to-consumer biotech skincare company based in Portland, OR, offering a clinically-advanced treatment system that combines growth factor-based skincare (C²+GF™ Complex using cytokine proteins) with at-home microneedling. The company was backed by Elevate VC. Crunchbase lists the company as permanently closed.

Deviceflow is an AI-native platform building a commercial operating system for medical device companies, automating operations such as order management, customer notifications, and ERP integrations. The company connects with accounting software and communication tools to streamline medical device sales and distribution workflows. Plug and Play Tech Center announced an investment in Deviceflow in April 2026.

Hemex Health develops point-of-care blood diagnostic devices that help healthcare providers diagnose, monitor, and manage chronic diseases worldwide. The company focuses on commercializing cost-effective, intuitive diagnostic tools to make testing more accessible. Hemex Health is headquartered in Portland, Oregon, with an additional presence in Mumbai, India.

Instinct Science is an animal health technology company providing veterinary practice management software designed to help hospitals stay efficient, ensure patient safety, and capture every charge. Its platform supports veterinarians and hospital staff with workflow tools, and in January 2026 acquired ScribbleVet to advance intelligent veterinary practice management.

Invio is a Seattle-based startup that develops FDA-compliant, cloud-based software to automate clinical trial workflows, replacing traditional paper and manual monitoring processes. The company makes clinical trials safer and faster through enterprise software for remote and automated trial monitoring. Invio was selected as the first company out of Madrona Venture Labs' accelerator in 2018.

InVivo Biosystems is a biotechnology company headquartered in Eugene, Oregon, that delivers expertise and technology to accelerate therapeutic discovery. The company uses its proprietary platform to advance drug discovery for neurological, metabolic, and rare monogenic diseases.

Jama Software delivers an AI-powered engineering management platform through its flagship product Jama Connect, which combines requirements management and Live Traceability™ to help engineering teams in complex product development. The platform is widely used in industries requiring rigorous traceability and requirements tracking, such as aerospace, automotive, and medical devices.

KitoTech Medical is a medical device company that makes the microMend® family of wound closure products, offering a less painful and cost-effective alternative to traditional sutures and staples. The devices are designed for both personal use and healthcare professionals. In 2022, KitoTech entered a distribution agreement with Corza Medical to market microMend Pro in the US.

Lumencor designs and manufactures solid-state light engines and illuminators for life science instrumentation, including fluorescence microscopes and cellular analysis systems. The company applies intelligent design to produce best-in-class photonics products, and has been recognized as a Top 10 Photonics Solutions Provider by Semiconductor Review Magazine.

Madorra is a medical device company focused on women's health that has developed a therapeutic ultrasound device to treat vaginal atrophy in breast cancer survivors. The device increases vasodilation and blood flow to improve vaginal health and female sexual function, and originated from the Stanford Biodesign program.

Myoaligner is a dental technology company offering an FDA-cleared patented system for the treatment of migraine headaches, TMJ disorders (TMJD), tension headaches, and restorative dentistry applications. The device provides a non-invasive solution for patients suffering from temporomandibular joint disorders and related conditions.

Neurosom develops medical devices and therapeutic protocols to improve sleep through psychological training and neurotechnology. The company has created a noninvasive sleep therapy system designed for personalized sleep improvement.

Obatala Sciences is a life sciences company founded in 2017 dedicated to advancing drug development through human-derived organ-on-a-chip research solutions, with a focus on obesity, diabetes, and regenerative medicine. The company commercially launched its ObaCell Obesity-on-a-Chip service, providing researchers with physiologically relevant in vitro models.