Accel Diagnostics is a medical diagnostics company developing proprietary point-of-care diagnostic assays for the diagnosis, monitoring, and management of various conditions. The company has proposed an innovative blood diagnostic test to aid the triage of patients presenting with head injuries, supported by SBIR funding.

Advanced Optronics is a medical device company co-founded by engineers from Carnegie Mellon University developing flexible, biocompatible micro-scale sensor systems for real-time AI guidance in surgery. Founded in 2021 to commercialize CMU research, the company has received NSF grant support.

ALung Technologies, Inc. is a Pittsburgh-based medical device company that developed low-flow extracorporeal carbon dioxide removal (ECCO2R) technologies for treating patients with respiratory failure. The company originated from the University of Pittsburgh and was acquired by LivaNova PLC in July 2022.

ARIEL Precision Medicine is a Pittsburgh, PA-based company pioneering the integration of genomic and clinical data to transform complex data into actionable healthcare insights. It has developed decision-support tools that integrate complex genetics into clinical decision making, focused on chronic diseases with high unmet need.

Astria Biosciences is a Pittsburgh-based startup developing blood-based diagnostics and small molecule inhibitors to combat cerebrovascular and neurovascular diseases. The company targets conditions such as aneurysm and craniofacial synostosis and has received NSF support.

Blue Belt Technologies, Inc. was a Pittsburgh-based medical device company that developed and commercialized robotics-assisted technologies for orthopedic surgery and other surgical specialties. The company was acquired by Smith & Nephew in October 2015.

Caliber Infosolutions, Inc. is a Pittsburgh, Pennsylvania-based company that designs informatics and IT solutions for scientific data processing needs, with a focus on quality management software for the pharmaceutical and life sciences industries. The company provides integrated quality management solutions for regulated industries.

Cassian Solutions is a healthcare technology company focused on patient and healthcare provider interactions within the specialty pharmacy and health plan sectors. Its ONE Journey™ platform delivers dynamic patient support programs with real-time insights for specialty care.

Cell X Technologies is a life sciences company pioneering advanced cell processing automation through its Celligent platform, designed to advance cellular and regenerative therapies. The company collaborates with reagent and biotech partners to standardize iPSC-based therapeutics and improve manufacturing for cell therapy innovators.

Cellumen, Inc. was a Pittsburgh, PA-based cellular systems biology company providing drug efficacy and toxicity prediction solutions. Founded with backing from Innovation Works, the company was acquired by Apredica (later Cyprotex) and partnered with firms such as Mitsubishi Tanabe Pharma Corporation.

CoExperiences is an event concierge platform headquartered in Pittsburgh, Pennsylvania, founded in 2020 by Emily Stewart. The company uses AI to match people into small-group, in-real-life (IRL) experiences designed to improve organizational health, social wellness, and team connection.

Cognition Therapeutics, Inc. is a clinical-stage biopharmaceutical company headquartered in Purchase, New York, focused on the discovery and development of small-molecule therapeutics targeting age-related neurodegenerative diseases of the central nervous system and retina. The company trades on NASDAQ under the ticker CGTX.

Concordare Trials is a clinical trial technology company building the first digital protocol infrastructure for clinical research. The platform replaces traditional 300-page PDF study protocols with a structured digital format, redefining how studies move from design to execution and powering every downstream workflow in a trial.

CranioSense is a clinical-stage medical device company developing IPASS, a non-invasive technology that measures intracranial pressure in seconds using a forehead patch and handheld reader — without drilling into the skull or inserting a sensor. The company is on a mission to enable on-demand neurological insight and treatment.

CytoAgents is a clinical-stage biotechnology company developing innovative pharmaceutical products for life-threatening conditions. Its lead asset, CTO1681, is an oral small molecule immune modulator designed to prevent and treat Cytokine Release Syndrome and other inflammatory conditions through selective prostacyclin/prostaglandin receptor signaling.

D.Sole is a health technology company developing a smart insole system that uses multimodal sensors and machine learning for the early detection and monitoring of diabetic foot complications such as ulcers. The platform integrates with a clinical decision support system to advance lifelong mobility for patients with diabetes.

DermaBio is a precision medicine company developing a skin biomarker platform to improve diagnosis, monitoring, and treatment selection for chronic and autoimmune inflammatory diseases. Founded in 2022, the company applies dermatological biomarkers to enable more targeted therapeutic decisions.

Diamyd, Inc. (formerly Nurel Therapeutics) is a gene therapy company acquired by Diamyd Medical AB in December 2005. Originally focused on a proprietary targeted drug delivery technique called Nerve-Targeted Gene Delivery, the company was subsequently integrated into Diamyd Medical's diabetes pipeline.

Duo Oncology is a biotech company founded by oncologists that develops ultrasmall, tumor-penetrating nanomedicines delivering drug combinations to deep, difficult-to-target tumors. The company aims to redefine cancer care by reinvigorating the treatment landscape with tumor-responsive nanomedicine approaches.

Endolumik is a medical device company founded in Morgantown, West Virginia, developing fluorescence-guided surgical tools for laparoscopic and bariatric procedures. Its patented devices enhance visualization and safety during gastrointestinal surgery. San Juan Regional Medical Center introduced its novel fluorescent device to New Mexico in 2023.