Alfa-Ruby is a protein innovation company headquartered in St. Louis, MO that unlocks the full potential of alfalfa to produce high-performance plant protein. The company addresses the need for plant protein that does not compromise on taste, nutrition, or functionality compared to animal proteins. Founded in 2025, it is a privately held startup.

Archetype is a platform that transforms space planning and procurement for designers and developers, auto-generating on-spec layouts and curated product selections. The company is based in St. Louis, Missouri and is a recipient of an Arch Grants award.

ASL Aspire is an EdTech company based in St. Louis, MO that teaches STEM to K-12 deaf students and their teachers through American Sign Language. Its platform includes interactive arcade games, guided videos, practice modules, and quizzes to make learning STEM vocabulary in ASL engaging. The company has been recognized with a Global Impact Award from the Skandalaris Center at Washington University.

Astrapi is a St. Louis, MO-based communications technology company and world leader in nonstationary spectrum technology using spiral-based, non-periodic signal modulation. Its approach boosts spectral efficiency and provides robust signal protection for radio systems. Astrapi positions its spiral modulation as a game-changing advancement in wireless communications.

Bold Stone Creamery is a St. Louis-based startup developing a line of adult-focused ice cream flavors targeted at sales in St. Louis stadium venues. The company was selected as part of Arch Grants' 2024 annual cohort, receiving between $75,000 and $100,000 in seed funding from the St. Louis nonprofit. As a condition of the grant, Bold Stone Creamery relocated to St. Louis to grow its business in the region.

CoverCress is a St. Louis, Missouri agricultural biotechnology company that has developed a new cover crop — derived from field pennycress — that serves as both a sustainable cover crop and a cash crop for farmers, producing oil for renewable fuel and meal for animal feed.

Dad's Cookie Co. is a St. Louis, Missouri bakery that has been baking its original Scotch Oatmeal cookies since 1927. Cookies are baked daily and shipped free across the U.S. In 2024, a trio of brothers acquired the company, continuing its long-running south St. Louis tradition.

St. Louis independent plant-science research institute — anchor of its agtech cluster.

Kultevat Inc. is a St. Louis, Missouri biotechnology company that combines plant breeding and green process engineering to produce specialty natural rubber from Kazakh Dandelion (Taraxacum kok-saghyz). The company is located at the Helix Center in the 39 North innovation district.

MediBeacon is a St. Louis, Missouri-based medical technology company focused on advancing fluorescent tracer agents and their transdermal detection to help improve patient care, particularly in kidney function monitoring.

SentiAR is a St. Louis, Missouri-based digital health company developing holographic augmented reality technology for use during interventional medical procedures. Its AR platform provides physicians with a single real-time source of truth for intraoperative visualization.

Summersalt is a direct-to-consumer apparel brand headquartered in Clayton, Missouri, offering swimwear, cover-ups, clothing, and accessories for women. Founded in 2017, the company focuses on flattering, sustainable swimwear with over 250 styles. It positions itself as a generation-defining brand for women who travel.

Wugen is a clinical-stage biotechnology company based in St. Louis, Missouri, focused on developing cellular therapies. The company conducts research at its facility at 4260 Forest Park Avenue in St. Louis.