Alfa-Ruby is a protein innovation company headquartered in St. Louis, MO that unlocks the full potential of alfalfa to produce high-performance plant protein. The company addresses the need for plant protein that does not compromise on taste, nutrition, or functionality compared to animal proteins. Founded in 2025, it is a privately held startup.

Archetype is a platform that transforms space planning and procurement for designers and developers, auto-generating on-spec layouts and curated product selections. The company is based in St. Louis, Missouri and is a recipient of an Arch Grants award.

Bold Stone Creamery is a St. Louis-based startup developing a line of adult-focused ice cream flavors targeted at sales in St. Louis stadium venues. The company was selected as part of Arch Grants' 2024 annual cohort, receiving between $75,000 and $100,000 in seed funding from the St. Louis nonprofit. As a condition of the grant, Bold Stone Creamery relocated to St. Louis to grow its business in the region.

Kultevat Inc. is a St. Louis, Missouri biotechnology company that combines plant breeding and green process engineering to produce specialty natural rubber from Kazakh Dandelion (Taraxacum kok-saghyz). The company is located at the Helix Center in the 39 North innovation district.