Dimien was a Buffalo, NY-based battery and clean energy technology startup that originated in a University at Buffalo lab. The company developed advanced battery and chemical manufacturing solutions in the clean energy sector. In October 2024, Dimien was acquired by Pure Lithium, a Boston-based lithium metal battery firm, marking a milestone for the Western New York clean tech ecosystem.

Rarebird is a Buffalo, New York-based consumer beverage company that produces Px Coffee, billed as the first jitterless coffee. The product replaces caffeine with paraxanthine (Px) to deliver clean, steady energy and sharper focus without jitters, crashes, or sleep disruption. Rarebird received strategic investment from 43North, a Buffalo-based accelerator, and relocated its headquarters to Buffalo as part of that partnership.

Uncaged Innovations is a biomaterials company founded by Stephanie Downs and Dr. Xiaokun Wang that engineers premium, sustainable biomaterials and cruelty-free leather alternatives for global brands. The company combines natural science and technology to reimagine leather with sustainable biomaterials. While listed with an Albany, NY association, the company's LinkedIn lists New York as its headquarters.