KC Drone Co. was a Kansas City-based drone services company; the business was sold in 2019.

Boat Planet is a St. Louis, MO-based web platform founded in 2018 where boat owners can find, compare, and book trusted and reviewed marine service professionals. The company is headquartered at 4220 Duncan Avenue, Suite 201 in Saint Louis and operates as a small privately held firm connecting boat owners with vetted marine pros.

Intelligent operating system for real estate development -- AI, real-time data, and project connectivity to streamline decisions from concept to construction across all asset types. LaunchKC 2026 cohort ($60K non-dilutive grant).

AirSeal CardioVascular Inc. is a medical diagnostics company headquartered at 4340 Duncan Ave, St. Louis, MO, focused on transforming the detection and management of peripheral arterial disease (PAD). The company was founded in 2022 and is privately held.

Alfa-Ruby is a protein innovation company headquartered in St. Louis, MO that unlocks the full potential of alfalfa to produce high-performance plant protein. The company addresses the need for plant protein that does not compromise on taste, nutrition, or functionality compared to animal proteins. Founded in 2025, it is a privately held startup.

Allumin8 is a St. Louis-based medical device startup that develops FDA-cleared spinal fixation systems designed to reduce reoperation rates in spine surgery. The company's proprietary porous implant design allows surgeons to diagnose, treat, and accelerate healing directly through the implant. Allumin8 received FDA clearance in November 2025, becoming the first medical device company to achieve this milestone for its innovative hardware.

Archetype is a platform that transforms space planning and procurement for designers and developers, auto-generating on-spec layouts and curated product selections. The company is based in St. Louis, Missouri and is a recipient of an Arch Grants award.

ASL Aspire is an EdTech company based in St. Louis, MO that teaches STEM to K-12 deaf students and their teachers through American Sign Language. Its platform includes interactive arcade games, guided videos, practice modules, and quizzes to make learning STEM vocabulary in ASL engaging. The company has been recognized with a Global Impact Award from the Skandalaris Center at Washington University.

Astrapi is a St. Louis, MO-based communications technology company and world leader in nonstationary spectrum technology using spiral-based, non-periodic signal modulation. Its approach boosts spectral efficiency and provides robust signal protection for radio systems. Astrapi positions its spiral modulation as a game-changing advancement in wireless communications.

Aware Vehicles is a Kansas City drone-tech startup building autonomous drones with smart docking platforms for construction, structural inspection, and imaging.

Balto is a St. Louis, MO-based contact center AI software company, founded in 2017, offering real-time agent guidance, automated quality assurance, business insights, coaching, and call summarization. Its platform is designed to help contact center agents perform better during live calls and improve overall team performance.

St. Louis agricultural-science division (the former Monsanto) — global crop science.

BenefitsBoost is a St. Louis, MO-based company that is revolutionizing the Social Security disability benefits process by making disability benefits applications faster and more accessible. The company serves disability advocacy groups and individuals, providing tools to streamline the benefits application experience.

Benson Hill was an agriculture technology company founded in 2012 and headquartered in St. Louis, Missouri, focused on sustainable food innovation using crop biology. The company filed for Chapter 11 bankruptcy protection in March 2025, with its assets and work subsequently picked up by Confluence Genetics.

Big Bang was a Kansas City IoT/smart-city software startup that built a cloud platform connecting devices for cities and businesses.

Boddle Learning, based in Kansas City, makes Boddle, a 3D game-based learning app teaching K-6 math, reading, and science.

Bold Stone Creamery is a St. Louis-based startup developing a line of adult-focused ice cream flavors targeted at sales in St. Louis stadium venues. The company was selected as part of Arch Grants' 2024 annual cohort, receiving between $75,000 and $100,000 in seed funding from the St. Louis nonprofit. As a condition of the grant, Bold Stone Creamery relocated to St. Louis to grow its business in the region.

Centene Corporation is a leading managed care organization headquartered in St. Louis, Missouri, providing access to high-quality healthcare solutions for families and individuals. The company operates as a government-sponsored managed care plan across multiple states. Its corporate headquarters is located at 7700 Forsyth Boulevard, St. Louis, MO 63105.

CodeAlgo Academy is a Kansas City-based, Black-female-founded 3D computer science gaming platform teaching K-8 students to code.

CoverCress is a St. Louis, Missouri agricultural biotechnology company that has developed a new cover crop — derived from field pennycress — that serves as both a sustainable cover crop and a cash crop for farmers, producing oil for renewable fuel and meal for animal feed.