JuneBrain Inc. is a Maryland-based medical technology company that develops telehealth OCT (optical coherence tomography) devices and AI software for remote monitoring of neurological and retinal diseases. The company's mission is to empower the ophthalmology and neurology communities through accessible monitoring of eye and brain health.

Testa-Seat is a developer of affordable, tailored, 3D-printed seating solutions designed to enhance mobility and independence for individuals with disabilities. The company produces custom booster and floor seats for children and collaborates with clinics, organizations, therapists, and foundations.

Sharp Therapeutics is a preclinical-stage drug discovery company headquartered in Pittsburgh, Pennsylvania, focused on developing therapeutics for genetic diseases. The company combines high-speed experimentation and modern computational methods with an accelerated clinical development path available in genetic disease. Its monogenic disease focus is designed to de-risk the clinical path.

Accel Diagnostics is a medical diagnostics company developing proprietary point-of-care diagnostic assays for the diagnosis, monitoring, and management of various conditions. The company has proposed an innovative blood diagnostic test to aid the triage of patients presenting with head injuries, supported by SBIR funding.

Advanced Optronics is a medical device company co-founded by engineers from Carnegie Mellon University developing flexible, biocompatible micro-scale sensor systems for real-time AI guidance in surgery. Founded in 2021 to commercialize CMU research, the company has received NSF grant support.

Aethon, Inc. is a provider of autonomous mobile robots for the healthcare and hospitality markets, automating routine delivery and transportation tasks to support clinical teams and staff. The company is a subsidiary of ST Engineering and serves hospitals with secure, autonomous delivery solutions.

ALung Technologies, Inc. is a Pittsburgh-based medical device company that developed low-flow extracorporeal carbon dioxide removal (ECCO2R) technologies for treating patients with respiratory failure. The company originated from the University of Pittsburgh and was acquired by LivaNova PLC in July 2022.

ARIEL Precision Medicine is a Pittsburgh, PA-based company pioneering the integration of genomic and clinical data to transform complex data into actionable healthcare insights. It has developed decision-support tools that integrate complex genetics into clinical decision making, focused on chronic diseases with high unmet need.

Astria Biosciences is a Pittsburgh-based startup developing blood-based diagnostics and small molecule inhibitors to combat cerebrovascular and neurovascular diseases. The company targets conditions such as aneurysm and craniofacial synostosis and has received NSF support.

BIOSAFE, Inc. was a polymer manufacturer developing personal care polymers for personal care, consumer, and healthcare products. The company was acquired by Gelest, a specialty silicone and metal-organic chemical company.

Blue Belt Technologies, Inc. was a Pittsburgh-based medical device company that developed and commercialized robotics-assisted technologies for orthopedic surgery and other surgical specialties. The company was acquired by Smith & Nephew in October 2015.

Buoy Hydration makes liquid electrolyte drops that transform any drink into a hydrating, functional beverage with trace minerals and no sugar. The company offers clean hydration supplements and immune support products designed for everyday wellness.

Caliber Infosolutions, Inc. is a Pittsburgh, Pennsylvania-based company that designs informatics and IT solutions for scientific data processing needs, with a focus on quality management software for the pharmaceutical and life sciences industries. The company provides integrated quality management solutions for regulated industries.

Cassian Solutions is a healthcare technology company focused on patient and healthcare provider interactions within the specialty pharmacy and health plan sectors. Its ONE Journey™ platform delivers dynamic patient support programs with real-time insights for specialty care.

Cell X Technologies is a life sciences company pioneering advanced cell processing automation through its Celligent platform, designed to advance cellular and regenerative therapies. The company collaborates with reagent and biotech partners to standardize iPSC-based therapeutics and improve manufacturing for cell therapy innovators.

Cellumen, Inc. was a Pittsburgh, PA-based cellular systems biology company providing drug efficacy and toxicity prediction solutions. Founded with backing from Innovation Works, the company was acquired by Apredica (later Cyprotex) and partnered with firms such as Mitsubishi Tanabe Pharma Corporation.

Circadiance LLC develops, manufactures, and markets remote patient monitoring products and soft cloth CPAP masks for sleep apnea treatment. The company is known for its SleepWeaver line of lightweight nasal CPAP masks and connects healthcare professionals with patients remotely. Circadiance received ISO 13485 certification and has cleared multiple devices through the FDA.

CoExperiences is an event concierge platform headquartered in Pittsburgh, Pennsylvania, founded in 2020 by Emily Stewart. The company uses AI to match people into small-group, in-real-life (IRL) experiences designed to improve organizational health, social wellness, and team connection.

Cognition Therapeutics, Inc. is a clinical-stage biopharmaceutical company headquartered in Purchase, New York, focused on the discovery and development of small-molecule therapeutics targeting age-related neurodegenerative diseases of the central nervous system and retina. The company trades on NASDAQ under the ticker CGTX.

Concordare Trials is a clinical trial technology company building the first digital protocol infrastructure for clinical research. The platform replaces traditional 300-page PDF study protocols with a structured digital format, redefining how studies move from design to execution and powering every downstream workflow in a trial.