Biosimilar Solutions is a global biosimilar company headquartered in Aguadilla, Puerto Rico, committed to expanding patient access to life-changing biologic medicines. The company operates in a PRIDCO facility in Aguadilla and announced in 2026 a GMP biomanufacturing plant exceeding 95,000 sq ft of cleanroom space in partnership with OcyonBio.

San Juan-based insurance holding company and largest medical insurer in Puerto Rico, operating as the Blue Cross Blue Shield licensee for managed care, life, and property & casualty insurance; acquired by GuideWell Mutual Holding in 2022 but continues operating under the Triple-S brand.

San Juan-headquartered, NYSE-listed (EVTC) payment-technology and transaction-processing company operating the ATH debit network and processing over ten billion transactions annually across Puerto Rico and Latin America.

Global pharma; Puerto Rico (U.S.) manufacturing in Barceloneta and Jayuya.

Global biotech; flagship Puerto Rico (U.S.) plant in Juncos produces a large share of Amgen product.

Fast-acting sublingual drug-delivery formulations. Puerto Rico (U.S.) pharma.

Global pharma (US base Wilmington DE); Puerto Rico (U.S.) manufacturing in Guayama.

Puerto Rico (U.S.)-headquartered major bank; finances the local manufacturing and consumer economy.

Global med-device/pharma; Puerto Rico (U.S.) manufacturing in Aibonito, Jayuya, Guayama.

Global med-device; Puerto Rico (U.S.) plant in Dorado produces ~100% of its global cardiac-rhythm-management leads.

Global pharma; Puerto Rico (U.S.) biologics in Manati and Humacao (Opdivo, Yervoy, Eliquis).

Cell therapy and cancer immunotherapy. Puerto Rico (U.S.) biotech — the overlooked local life-sciences economy.

Ultra-luxury oceanfront resort in Dorado, Puerto Rico built on the historic Laurance Rockefeller property, operated under Ritz-Carlton's Reserve brand with two 18-hole golf courses; a magnet property for Act 60 investor relocation to the island.

Global pharma; major Puerto Rico (U.S.) manufacturing — insulin/biologics (Carolina) and Mayaguez.

San Juan-headquartered bank holding company (NYSE: FBP) for FirstBank Puerto Rico, the island's first savings and loan institution (est. 1948), serving retail, commercial and institutional clients in Puerto Rico, the U.S. and British Virgin Islands, and Florida.

Business-process-outsourcing center opened by Infosys BPO in Puerto Rico in collaboration with PRIDCO and the Commonwealth government, providing back-office and transaction-processing services from San Juan.

San Juan-headquartered, fully integrated real estate development, construction and asset-management platform founded in 1977; developer of Bahía Beach Resort & Golf Club residences and the Cosmopolitan condominium tower, having sold over 3,200 residential units across Puerto Rico.

Johnson & Johnson is a global healthcare company headquartered in New Brunswick, NJ, focused on preventing and curing complex diseases through smarter, less invasive treatments and personalized solutions. It was the first innovative healthcare company founded in New Jersey.

San Juan-headquartered subsidiary of Spanish insurer MAPFRE, operating six offices across Puerto Rico offering auto, home, life and business insurance.

GTPase-inhibitor oncology compounds (R&D stage). Puerto Rico (U.S.) biotech.