Pulumi is a Seattle-based open source infrastructure as code platform that enables developers and operators to build and manage cloud infrastructure using real programming languages including Node.js, Python, Go, .NET, Java, and YAML. The company is headquartered in Seattle with teams around the world serving thousands of cloud engineering teams.

Digital freight network. Seattle WA. Gates Ventures + Greylock. $3.8B valuation 2022. Ceased operations 2023 — notable shutdown.

Corporate Tools is a Spokane, Washington-based company that builds software and services to make starting, running, and organizing a business easier. Its offerings include LLC filings, registered agent service, identity management software, website and domain registration, and digital address services. The company serves lawyers, accountants, secretaries, and business owners.

Absci is a clinical-stage biopharmaceutical company headquartered in Vancouver, Washington that uses generative AI to design and develop differentiated drug therapeutics. Founded in 2011, Absci is publicly traded on Nasdaq (ABSI).

Adaptive Biotechnologies is a Seattle-based pioneer in immune-driven medicine that harnesses the adaptive immune system as a natural diagnostic and therapeutic tool. The company decodes and deploys the immune system's capabilities to improve patient lives and propel a paradigm shift in medicine.

Seattle WA. Non-profit AI research institute founded by Paul Allen (Microsoft co-founder, 2014). Largest 501c3 nonprofit AI research org in world. 200+ researchers. $100M+ annual funding from Paul Allen estate. CEO: Peter Clark (interim May 2026, after Ali Farhadi departed to Microsoft). Key: OLMo (fully open 32B LLM outperforms GPT-4o mini), Tulu (instruction tuning), PRIOR (computer vision), Semantic Scholar, EarthRanger. $152M NSF+Nvidia OMAI project (Aug 2025) — open AI infrastructure for science. AI2 Incubator: co-founds startups, $600K + $1M cloud credits, ~7% common stock. Deep UW Paul G. Allen School partnership (PI Noah Smith dual-appointed).

Seattle WA. Non-profit neuroscience research institute founded by Paul Allen (2003, $100M founding gift — his first major science philanthropy). Part of Allen Institute umbrella (alongside AI2 and Allen Institute for Cell Science). Flagship product: Allen Brain Atlas — free, open-access database of gene expression in mouse and human brains, used by 90%+ of neuroscience researchers globally. Allen Cell Types Database. Allen Mouse Brain Connectivity Atlas. $100M+ annual budget from Paul G. Allen estate. Deep UW Medicine partnership. CEO: Christof Koch (leading consciousness researcher, 2011-2023); now Allan Jones. Brain science → AI feedback loop: Brain Atlas data used extensively in training neural network architectures. Precursor intellectual lineage to AI2. Both AIBS and AI2 are Paul Allen legacy institutions — managed under same philanthropic umbrella.

Altek is a family-owned contract manufacturer headquartered in Spokane Valley, WA that provides full-service, integrated product realization services for the aerospace, space, and medical industries. The company is recognized for delivering innovative manufacturing solutions and exceptional quality.

Dave Brown, longtime Amazon Web Services executive who ran AWS' compute and machine learning services and the Trainium AI chip business, is departing the cloud provider. Dave Treadwell from Amazon's commerce group will replace him. The move comes as AWS accelerates revenue growth serving large AI customers like Anthropic and OpenAI.

Industrial protein-design company using physics-based computational design, AI, and lab automation; co-founded by Nobel laureate David Baker out of the University of Washington's Institute for Protein Design.

Augmodo, a Seattle wearable camera badge startup for retail and operations teams, raised $21M at $350M post-money valuation. Round led by TQ Ventures with participation from Lerer Hippeau, Jefferson River Capital, and others.

Walla Walla, WA mushroom farm + community agriculture — grows/sells mushroom varieties (online market, farmers markets, grocery/restaurant supply, soil amendments, education / farm-to-school). "More than mushroom growers — community builders"; People/Planet/Profit. Runs the Persistent Local Market (indoor winter market) and the Choice Mushroom Collective (regional grower collaboration). Locally owned. Operator-supplied 2026-06-26.

Richland WA public-power JV operating Columbia Generating Station — the Pacific Northwest's only commercial nuclear plant.

$4.2B AUM. Seattle growth equity focused exclusively on healthcare. One of largest dedicated healthcare VCs in US.

Walla Walla, WA — a donation-based mushroom culture library + spawn laboratory: mushroom species, liquid cultures, grow kits, substrate, agar media, free education (videos, Q&A, workshops). Ethos = OPEN-SOURCE MYCOLOGY ("genetics are of the commons, accessible to anyone willing to maintain them"); DIY, sustainability, fungi-as-allies, rejecting purely profit-driven biological conservation. "Homegrown in Walla Walla." Operator-supplied 2026-06-26.

Seattle enterprise VC. $250M raised 2023. Founded by ex-Ignition and ex-Madrona partners. Next decade of enterprise innovation thesis.

Gestalt Diagnostics is a Spokane, Washington-based pathology technology company that combines digital pathology, AI, and enterprise IT services to support efficient clinical operations. In May 2025, the company raised $7.5 million in Series A funding to facilitate broader market adoption of its AI-powered digital pathology platform.

Sales enablement platform. Seattle WA. ICONIQ Growth + Tiger Global. $3.5B valuation 2021.

Building a satellite constellation that turns any Bluetooth-enabled device into a trackable, connected node without cellular service or extra hardware.