EPI (Engineered Products of Ohio, LLC) is a Cortland, OH-based technology manufacturing company founded in 2016 that custom designs Radio Frequency Identification (RFID) tags and related products for industrial and commercial applications.

FenixPyre is a data security software company headquartered in Ohio that provides a Post-Authentication Data Security (PADS) platform. Its technology prevents ransomware, mitigates insider threats, and enforces third-party risk management (TPRM) by blocking bad actors after authentication — the stage where 74% of breaches succeed.

Foxconn-operated EV manufacturing at the former GM / Lordstown Motors plant — contract EV production in the Mahoning Valley.

JuggerBot 3D is a Youngstown, Ohio-based additive manufacturing machine builder that designs and builds industrial-grade large-format 3D printing systems for functional thermoplastics and composites. The company serves industrial clients with both equipment and production services. It operates under the mission to deliver the finest 3D printing solutions in the world.

LeapFast Manufacturing is an advanced manufacturing company headquartered in Youngstown, OH and operating out of the Youngstown Business Incubator (YBI) that specializes in friction stir welding (FSW) to produce high-strength components for infrastructure, defense, and aerospace applications. The company focuses on enabling sustainable growth of infrastructure through advanced manufacturing capabi

EV-truck startup (the Endurance pickup) that took over the former GM Lordstown plant; filed Chapter 11 (2023), assets to Foxconn. The flagship of Youngstown's EV pivot.

MedaSync is a payer-aware AI platform built for skilled nursing facilities (SNFs) that uncovers reimbursement risk and opportunity across PDPM, CMI, QIP, and managed care. Headquartered in Youngstown, OH, MedaSync helps SNFs improve reimbursement accuracy and optimize financial performance. In 2025, the company secured a strategic investment from Omega Healthcare Investors.

MedPilot is an AI-driven patient engagement platform that personalizes outreach based on patient characteristics to improve healthcare engagement. The company, which participated in the Youngstown Business Incubator, was acquired by Vytalize Health in February 2021.

OhanaLink Technologies is a Hermitage, PA-based mobile technology startup that has developed a proprietary platform to connect employees and employers. Its OhanaLink at Work program has been adopted by local employers and the City of Hermitage to support workforce communication and engagement.

S4 Medical is a medical device company headquartered in Youngstown, OH, focused on developing solutions for safer catheter ablation treatment for atrial fibrillation. Its lead product, the Esolution, is an FDA-cleared esophageal deflection device designed to reduce the risk of thermal injury during AF ablation procedures. The company raised financing for the Esolution device in 2023.

Strangpresse is a Warren, Ohio-based manufacturer of high-performance thermoplastic extruders for 3D printing and additive manufacturing applications. Founded in 2014 and located at 900 Pine Ave SE, the company designs lightweight, fully controllable extrusion heads. Strangpresse has a licensing partnership with Oak Ridge National Laboratory (ORNL) for its extruder technology.

Tailored Alloys is a Youngstown, Ohio-based advanced manufacturing company developing software and hardware to unlock the potential of laser powder bed fusion (metal 3D printing) for applications including hypersonic and other high-performance use cases. The company's patent-pending process centers on alloy evaluation and optimization, and it has received support from the Youngstown Business Incub

TonDone is a business operating system for building and facility service companies, providing field service management software that simplifies scheduling, operations, and workflows. The Ohio-based company raised $1.5 million in seed funding led by Valley Growth Ventures, announced in April 2022.

GM–LG Energy Solution JV EV-battery gigafactory in Lordstown OH (operating) — cornerstone of the Mahoning Valley's auto/EV reinvention.

Public university in Youngstown — engineering, advanced manufacturing, business.