Second Porch was a Portland, Oregon-based online marketplace for vacation home rentals. The company connected property owners with travelers seeking short-term accommodations and was acquired by HomeAway in May 2011.

Sella Group is a private, independent Italian holding company with offices in Italy and abroad, operating in banking, fintech, and financial services. It founded and supports the Fintech District of Milan and launched the first open banking platform in Italy. In 2025, its banking arm Banca Sella acquired full control of digital banking platform Hype for €85 million.

Sentry is a developer-first application performance monitoring and error tracking platform, headquartered in San Francisco, CA. It helps engineering teams detect, trace, and resolve issues faster across web and mobile applications, and is available as both an open-source project and a hosted SaaS product.

SHYFT Power Solutions is an energy technology company focused on enabling an energy revolution for underserved consumers in emerging markets. It builds IoT and integrated software solutions to optimize energy asset performance across solar, battery, grid, and generator systems, offering real-time sub-metering and energy monitoring.

Sightbox was a Portland-based subscription service for contact lens wearers, founded in 2015, that charged members $39 per month to cover annual eye exams and contact lenses. Johnson & Johnson acquired Sightbox in 2017, and J&J Vision subsequently shut down the service in 2019.

SkySquad is an airport assistance service operating across U.S. airports, providing on-demand help for parents, seniors, and travelers who need translation or navigation support. Its agents offer departure, connection, and arrival assistance, including express service to gates and baggage carry. Denver International Airport was among the first major airports to introduce SkySquad to travelers.

SmartRG is a developer and manufacturer of networking equipment focused on residential and small business gateway solutions, including modems and whole-home Wi-Fi platforms for internet service providers. The company was acquired by ADTRAN in December 2018, adding its connected-home software platform and cloud services to ADTRAN's networking portfolio.

Snap2Insight is an AI startup that provides image recognition solutions for retail execution analytics, serving CPG brands, retailers, and merchandisers. Its technology converts shelf photos into real-time metrics to help optimize merchandising and sales performance. The company uses deep learning to deliver actionable insights at the point of sale.

Solace Health is a patient advocacy platform that connects Medicare and other patients with expert patient advocates to help navigate the healthcare system. The company raised a $130 million Series C led by IVP in February 2026, reaching a $1 billion valuation, and operates a HIPAA-compliant full-stack platform integrating patient intake, advocate workflows, and physician oversight.

Solid Carbon develops low-carbon concrete additives aimed at turning concrete from a carbon emitter into a climate solution through carbon-negative construction. The company offers sustainable concrete products designed to reduce embodied carbon in the built environment.

SomnoSeal is a medical device company that makes a patient-friendly oral seal designed to help CPAP users who breathe through their mouths. The SomnoSeal device enables mouth breathers to comfortably use smaller nasal or nasal pillow style CPAP masks, which are generally better tolerated than full-face masks. It has been featured in dental sleep medicine publications as an effective solution for improving CPAP therapy compliance.

SOURCE Global (also known as Source) is a Scottsdale, Arizona-based technology company that manufactures Hydropanels — devices that use air and sunlight to produce safe, clean drinking water. Its technology serves industrial, commercial, residential, and community applications, providing an independent water supply independent of traditional infrastructure.

Stiira is a cloud-based leave management software solution that streamlines leave of absence administration for employers and third-party administrators. The platform simplifies the complexity of managing employee leave, reducing administrative burden and improving the employee experience. Stiira launched its leave management product in April 2024.

StrateSea Technology is an AI/ML software company that develops solutions for the hydrographic and marine intelligence space. Its platform integrates acoustic, optical, sonar, radar, and other sensor data types into a unified analysis workflow, transforming complex marine sensor data into actionable intelligence. The company focuses on computer vision and analysis tools for maritime applications.

Streem is a remote video and augmented reality platform that enables companies to see what their customers see in real time, reducing support diagnosis and resolution times. Its enterprise product, StreemCore, is a no-download video tool available on Salesforce AppExchange, used by home service professionals and customer support teams.

Sturdy is a Portland-based AI startup that provides a customer intelligence platform analyzing unstructured customer communications across multiple channels to identify churn risks and surface actionable signals. The platform delivers account reviews, QBR summaries, risk alerts, and role-based updates without requiring code to deploy. Sturdy raised $6 million in April 2025.

SurgiVance is a medical technology company developing advanced diagnostic imaging technologies using optics to bring rapid pathology diagnosis to the point of care. The company received a Phase II SBIR grant to commercialize its direct-to-digital pathology imaging platform and initiated a New York State-funded clinical pilot project.

SyncFloor is a curated marketplace of commercial music for use in advertisements, film, TV, games, and podcasts. Built by music experts, it offers natural language-powered music discovery and hassle-free licensing for creative professionals. The platform opened publicly in 2020.

SynPlexity is a biotech startup founded by University of Oregon professor Calin Plesa that commercializes DropSynth technology for scalable, parallel DNA synthesis. Its platform enables creation of multiplex gene libraries for applications in therapeutics, biomanufacturing, and agriculture, producing longer sequences at lower cost than competing technologies.