RISE Brewing Co. makes USDA Organic nitro cold brew coffee, tea, and oat milk beverages. The company's products are non-GMO, dairy-free, and available nationally, with its flagship nitro cold brew delivering 180mg of natural caffeine per can.

RNA Networks was a Portland, Oregon-based software company that developed the Memory Virtualization Platform (MVP), enabling groups of servers to share pools of memory across a network for high-performance business applications. Dell acquired RNA Networks in June 2011 to integrate its memory virtualization technology into Dell's systems, storage, and networking product lines.

Rock Paper Coin is a contract, invoice, and payment automation platform purpose-built for wedding and event professionals. It provides templates, payment processing, and alerts accessible via desktop or mobile. The company reports that 84% of its invoices are paid promptly through the platform.

Rockhopper is a spreadsheet accuracy platform for finance professionals, providing version control, an Excel add-in, cell-level change tracking, and AI-powered review for Excel and Google Sheets. It brings clarity to workbook changes without requiring new tools or workflows.

Rook (formerly RookMotion) is a health data platform that connects companies with wearable and fitness data to enable more meaningful wellness and health experiences. The company raised $1.7M in pre-seed funding in March 2023, led by NuFund Venture Group, to expand its health data connectivity platform.

Roost is a smart home telematics company headquartered in Sunnyvale, CA, that develops a patent-pending connected platform for homeowners and commercial insurance. Founded in 2014 by James Blackwell and Roel Peeters, Roost offers in-home IoT solutions that transform how insurers engage with policyholders.

RootNote is a Nashville-based music technology company that helps managers and management companies track artist social profiles alongside private and first-party data. Founded by brothers Jason and Jeremy Burchard, it works with entrepreneurial artists to build companies around their music, and announced its inaugural artist investments in 2018.

RPC, Inc. is an oil and gas services company that provides specialized services to the energy industry through multiple service lines including well control training, tubular services, and completion services. The company operates through subsidiaries such as CUDD Energy Services, Patterson Services, and ThruTubing Solutions.

Ruckus Components is a Portland, Oregon-based company specializing in the design, repair, and manufacturing of carbon fiber bicycle products. The company has been working with carbon fiber components since at least 2009, offering services backed by science and engineering expertise.

Rumpl is a Portland, OR-based outdoor blanket company that makes high-performing blankets using technical materials commonly found in outdoor gear and activewear. The company is a certified B Corporation and is certified carbon neutral through The Climate Label, sourcing environmentally responsible materials and offsetting 100% of its carbon emissions.

Run Energy is a specialist services and products provider for the energy and environmental industries worldwide, offering operations, maintenance, installation, and technical services. The company has particular expertise in the distributed energy sector, including landfill gas-to-energy (LFGE) and energy-from-waste applications.

RYSE Supplements is a company that manufactures and sells dietary supplements including protein powders, pre-workout drinks, creatine, and hydration products, as well as energy drinks and branded merchandise. The company offers products in various flavors, often in collaboration with established food brands, and provides options for customers to build custom supplement bundles.

Salt & Straw is a Portland, Oregon-based small-batch, craft ice cream company that makes chef-driven flavors using local ingredients and offers nationwide delivery. Founded with a single ice cream cart in Northeast Portland, the company has grown to more than 50 locations and reports over $100 million in annual sales.

Salt & Straw is a craft ice cream company headquartered in Portland, Oregon, known for small-batch, chef-driven flavors handmade using local ingredients. The company operates scoop shops across the US and offers nationwide delivery of its ice cream pints online.

SavorEase (also styled Savorease) makes dissolvable, plant-based savory finger foods designed for people with dysphagia and chewing difficulties. Founded in 2015 by culinary chef and oral reconstruction specialist Dr. Reva Barewal, the company focuses on nutrition and dining enjoyment for adults and children on therapeutic or restricted diets.

Second Porch was a Portland, Oregon-based online marketplace for vacation home rentals. The company connected property owners with travelers seeking short-term accommodations and was acquired by HomeAway in May 2011.

Sella Group is a private, independent Italian holding company with offices in Italy and abroad, operating in banking, fintech, and financial services. It founded and supports the Fintech District of Milan and launched the first open banking platform in Italy. In 2025, its banking arm Banca Sella acquired full control of digital banking platform Hype for €85 million.

Sentry is a developer-first application performance monitoring and error tracking platform, headquartered in San Francisco, CA. It helps engineering teams detect, trace, and resolve issues faster across web and mobile applications, and is available as both an open-source project and a hosted SaaS product.

SHYFT Power Solutions is an energy technology company focused on enabling an energy revolution for underserved consumers in emerging markets. It builds IoT and integrated software solutions to optimize energy asset performance across solar, battery, grid, and generator systems, offering real-time sub-metering and energy monitoring.