Sightbox was a Portland-based subscription service for contact lens wearers, founded in 2015, that charged members $39 per month to cover annual eye exams and contact lenses. Johnson & Johnson acquired Sightbox in 2017, and J&J Vision subsequently shut down the service in 2019.

SkySquad is an airport assistance service operating across U.S. airports, providing on-demand help for parents, seniors, and travelers who need translation or navigation support. Its agents offer departure, connection, and arrival assistance, including express service to gates and baggage carry. Denver International Airport was among the first major airports to introduce SkySquad to travelers.

SmartRG is a developer and manufacturer of networking equipment focused on residential and small business gateway solutions, including modems and whole-home Wi-Fi platforms for internet service providers. The company was acquired by ADTRAN in December 2018, adding its connected-home software platform and cloud services to ADTRAN's networking portfolio.

Snap2Insight is an AI startup that provides image recognition solutions for retail execution analytics, serving CPG brands, retailers, and merchandisers. Its technology converts shelf photos into real-time metrics to help optimize merchandising and sales performance. The company uses deep learning to deliver actionable insights at the point of sale.

Solace Health is a patient advocacy platform that connects Medicare and other patients with expert patient advocates to help navigate the healthcare system. The company raised a $130 million Series C led by IVP in February 2026, reaching a $1 billion valuation, and operates a HIPAA-compliant full-stack platform integrating patient intake, advocate workflows, and physician oversight.

Solarcore is a materials technology company developing advanced aerogel-based thermal insulation products for consumer, commercial, and government applications. The company markets its solutions as the most advanced thermal insulation available, offering high performance across a range of industries.

Solid Carbon develops low-carbon concrete additives aimed at turning concrete from a carbon emitter into a climate solution through carbon-negative construction. The company offers sustainable concrete products designed to reduce embodied carbon in the built environment.

SomnoSeal is a medical device company that makes a patient-friendly oral seal designed to help CPAP users who breathe through their mouths. The SomnoSeal device enables mouth breathers to comfortably use smaller nasal or nasal pillow style CPAP masks, which are generally better tolerated than full-face masks. It has been featured in dental sleep medicine publications as an effective solution for improving CPAP therapy compliance.

Sseko Designs is a fair-trade fashion brand that produces handcrafted footwear and accessories in Uganda, employing high-potential women and providing them with sustainable income to fund their education. The company merged with Noonday Collection to become the world's largest fair-trade fashion brand powered by social selling.

Steamchain Corp is a B2B fintech company based in Portland, Oregon that simplifies global payments for logistics and shipping companies by reducing currency conversion costs and preventing fraudulent transactions. The company's platform has been in development since 2009 and received investment from Ideaship Fund.

Stiira is a cloud-based leave management software solution that streamlines leave of absence administration for employers and third-party administrators. The platform simplifies the complexity of managing employee leave, reducing administrative burden and improving the employee experience. Stiira launched its leave management product in April 2024.

StrateSea Technology is an AI/ML software company that develops solutions for the hydrographic and marine intelligence space. Its platform integrates acoustic, optical, sonar, radar, and other sensor data types into a unified analysis workflow, transforming complex marine sensor data into actionable intelligence. The company focuses on computer vision and analysis tools for maritime applications.

Streem is a remote video and augmented reality platform that enables companies to see what their customers see in real time, reducing support diagnosis and resolution times. Its enterprise product, StreemCore, is a no-download video tool available on Salesforce AppExchange, used by home service professionals and customer support teams.

Sturdy is a Portland-based AI startup that provides a customer intelligence platform analyzing unstructured customer communications across multiple channels to identify churn risks and surface actionable signals. The platform delivers account reviews, QBR summaries, risk alerts, and role-based updates without requiring code to deploy. Sturdy raised $6 million in April 2025.

SurgiVance is a medical technology company developing advanced diagnostic imaging technologies using optics to bring rapid pathology diagnosis to the point of care. The company received a Phase II SBIR grant to commercialize its direct-to-digital pathology imaging platform and initiated a New York State-funded clinical pilot project.

SyncFloor is a curated marketplace of commercial music for use in advertisements, film, TV, games, and podcasts. Built by music experts, it offers natural language-powered music discovery and hassle-free licensing for creative professionals. The platform opened publicly in 2020.

SynPlexity is a biotech startup founded by University of Oregon professor Calin Plesa that commercializes DropSynth technology for scalable, parallel DNA synthesis. Its platform enables creation of multiplex gene libraries for applications in therapeutics, biomanufacturing, and agriculture, producing longer sequences at lower cost than competing technologies.

Regional operating company (OpCo) of Sysco Corporation -- a distinct legal subsidiary per SEC filing (Exhibit 21.1, FY2020 10-K), serving the Sysco Portland area.

Tab is a Y Combinator-backed platform that gives independent tourism businesses tools to improve their online presence, be discovered by travelers, and take direct bookings. It is focused on revolutionizing the way travelers discover, plan, and book travel experiences directly with local operators.