Bold Reuse provides closed-loop reusable packaging systems for campuses, events, and venues, handling sanitation, logistics, and data to eliminate single-use waste. Headquartered in Portland, OR, the company has partnered with clients including the Portland Trail Blazers and McMenamins, and has set targets to reach 30 cities and $100 million in scale.

Boulder Care is a Portland, Oregon-based telehealth company providing addiction treatment for opioid, alcohol, and substance use disorders. It offers whole-person online care with a dedicated team of physicians, peer support specialists, and 24/7 availability grounded in unconditional support.

Brandlive is a Portland, Oregon-based SaaS company that develops virtual-event and video production software, bringing television-quality broadcast capabilities to corporate communications and live events. The company partners with large enterprises to create and stream branded content. It was founded and operates as a standalone software-and-services platform.

Brave Care was a Portland, Oregon-based pediatric urgent and primary care startup founded in 2019. The company operated clinic locations in Portland focused on delivering modern pediatric care. Brave Care permanently closed all locations in December 2024.

Breadwinner Cycles is a Portland, Oregon-based maker of handmade, custom bicycles for everyday riders. With more than 30 years of combined bicycle design and fabrication experience, the company ships its bikes worldwide.

Bright.md was an asynchronous telehealth company whose platform allowed providers to treat low-acuity conditions virtually without requiring real-time interactions, enabling patients and providers to exchange messages and respond to clinical questions on their own schedule. Its assets were acquired by 98point6 in early 2024.

Bright.md is a telemedicine software company that automates clinical intake, workflows, and administrative tasks to improve care encounters through asynchronous and video telehealth. Its cloud-based platform enables providers and patients to exchange messages and respond to questions outside of real-time visits. In January 2024, 98point6 acquired Bright.md's assets to expand its asynchronous telehealth capabilities.

BuildingLens is a software platform that helps building owners and managers improve indoor air quality and drive energy efficiency in small to medium-sized buildings. Founded by a team with experience in building science, energy management, and sustainability, the company has been recognized as an equitable cleantech startup and is based in Oregon.

Bumped is a Portland, OR-based fintech startup that allows consumers to earn fractional shares of stock as loyalty rewards for purchases made at partner retailers. The company raised $10.4M and launched a consumer app covering over 1,000 retailers. In 2022, Bumped partnered with Maritz Motivation to bring stock-based rewards to consumer loyalty programs broadly.

Candid (also known as CandidPro) is a clear aligner company that provides custom teeth-straightening solutions through a dentist and orthodontist network. Founded in 2017, it raised $15 million in early funding and originally offered a direct-to-consumer model before pivoting in 2022 to a dentist-partnered platform called CandidPro.

Caravel Bio is a Portland, Oregon–based synthetic biology startup building a novel protein evolution platform that creates proteins exceeding nature's bounds to serve as new protein machines. The company targets applications in critical minerals, carbon capture, and industrial processes using cell-free protein engineering methods.

CarbonBright is an AI-native sustainability platform offering automated Life Cycle Assessments (LCAs), Scope 3 supply chain tracking, Environmental Product Declarations (EPDs), and carbon footprint labeling. The company is on a mission to enable the world's transition to net-zero supply chains.

CarpeDM is a dating app and matchmaker service designed specifically for Black women, founded by Naza Shelley and Sali Hama. Launched officially in fall 2021 and based in Woodbridge, Virginia, the company originated in 2018 as Carpe Diem Social LLC and debuted as a video-first dating app MVP in 2019.

Cartogram provides next-generation indoor and outdoor wayfinding software exclusively to healthcare clients, enabling patients and staff to navigate from anywhere to anywhere — inside, outside, and between facilities. The platform is built in full compatibility with Epic MyChart and includes mapping, content creation, and hardware deployment services.

Cascade Prodrug is an oncology-focused biotechnology company developing a novel class of hypoxia-activated prodrug therapies that target diseases rooted in oxygen deprivation, including solid tumors and wet AMD. Its lead program, CPD100, is designed to selectively activate in hypoxic tissue. The company is led by seasoned pharmaceutical and biotech executives.

Chris King Precision Components is a Portland, OR-based manufacturer of premium bicycle components — including headsets, bottom brackets, hubs, and stems — that has produced investment-grade, USA-made components since 1976. All design, manufacturing, and assembly operations are performed under one roof in Portland.

Clean Age is a personal care brand created specifically for teenagers, offering deodorant, toothpaste tablets, and toothbrushes formulated with clean, natural ingredients. The company uses sustainable packaging and clean formulas designed to be safe for growing bodies and to help teens build healthy daily habits.

CleanHaus is an AI-powered property care and operations platform built for the short-term rental community, serving hosts, cleaners, and contractors. It automates cleaning coordination and scheduling to reduce operational stress and help deliver five-star guest experiences. The platform is accessible at clean.haus.

CleanHaus is a property management software company that connects short-term rental hosts' Airbnb and Vrbo bookings directly to their cleaning crews, automatically scheduling turnovers when reservations are created or modified. Built by hosts for hosts, the platform aims to eliminate missed cleanings and streamline turnover coordination.