Hemex Health develops point-of-care blood diagnostic devices that help healthcare providers diagnose, monitor, and manage chronic diseases worldwide. The company focuses on commercializing cost-effective, intuitive diagnostic tools to make testing more accessible. Hemex Health is headquartered in Portland, Oregon, with an additional presence in Mumbai, India.

HerdDogg is a data analytics company that develops Bluetooth-enabled smart ear tags for cattle that continuously monitor animal movement and temperature, generating real-time health alerts. The technology functions as a wearable health monitor for livestock, enabling ranchers to detect issues early and protect their herds.

Hest is a Seattle-based outdoor gear company that designs high-performance memory foam mattresses, pillows, and sleep accessories for camping and outdoor use. The company raised $2.7 million in Series A funding in October 2025 as its product line and retail partnerships drove growth.

Honey Mama's is a Portland, Oregon-based food company that makes refrigerated chocolate truffle bars and protein bars from a limited set of nutrient-rich superfoods with a 100% clean label. The company was founded at a local farmer's market and continues to produce its products in-house in Portland.

Hubb is a software platform that helps conference and meeting professionals plan, build, and manage onsite, virtual, and hybrid events from start to finish. The company reinvents how the world experiences events by bringing brands to life through its event management technology. Hubb was acquired by Notified and now operates as part of that platform.

Hubly is a practice management software platform designed for financial advisory firms, providing workflow management, task tracking, automations, and collaboration tools. Its operating system enables advisory firms to deliver a high-touch household experience at scale while ensuring nothing falls through the cracks.

Hue Noir is a cosmetics company offering inclusive makeup products formulated for women of color, including foundations, lipsticks, and lip gloss. It is the only makeup brand in the US owned, formulated, and manufactured by a Black woman cosmetic chemist. Products are available online and through select retail stores.

Hydrolix is a real-time data platform that delivers sub-second analytics at global scale, addressing runaway costs, slow query performance, and fragile clusters. Founded in 2018, the platform enables real-time analytics across globally distributed data at internet scale, serving use cases ranging from servers and applications to large-scale observability workloads.

iGridSim is a utility-based technology company developing AI-powered solutions for autonomous power grids. The company provides advanced modeling, analytics, and grid integration services to enhance flexibility, resilience, and support a net-zero electric grid.

Inpria Corporation manufactures EUV metal oxide photoresists designed to enable semiconductor manufacturers to realize the full potential of extreme ultraviolet (EUV) lithography. Its inorganic photoresists offer superior etch resistance, allowing chipmakers to simplify the manufacturing process by eliminating extra layers. Inpria was acquired by JSR Corporation in 2021.

Instinct Science is an animal health technology company providing veterinary practice management software designed to help hospitals stay efficient, ensure patient safety, and capture every charge. Its platform supports veterinarians and hospital staff with workflow tools, and in January 2026 acquired ScribbleVet to advance intelligent veterinary practice management.

Invio is a Seattle-based startup that develops FDA-compliant, cloud-based software to automate clinical trial workflows, replacing traditional paper and manual monitoring processes. The company makes clinical trials safer and faster through enterprise software for remote and automated trial monitoring. Invio was selected as the first company out of Madrona Venture Labs' accelerator in 2018.

InVivo Biosystems is a biotechnology company headquartered in Eugene, Oregon, that delivers expertise and technology to accelerate therapeutic discovery. The company uses its proprietary platform to advance drug discovery for neurological, metabolic, and rare monogenic diseases.

Jama Software delivers an AI-powered engineering management platform through its flagship product Jama Connect, which combines requirements management and Live Traceability™ to help engineering teams in complex product development. The platform is widely used in industries requiring rigorous traceability and requirements tracking, such as aerospace, automotive, and medical devices.

JourneyTrack is an AI-forward decision intelligence platform for enterprise customer journey management. It helps CX, product, and operations teams map, track, and optimize customer experiences using tools like Journey AI, Persona AI, and Storytelling AI to reduce churn, accelerate growth, and prove CX ROI.

Kickplan is a turnkey monetization and billing platform for growth-stage SaaS companies, providing a full billing backend faster and with more flexibility than in-house builds. Headquartered in Pasadena, California, the company was founded in 2023 and has received venture funding.

KitoTech Medical is a medical device company that makes the microMend® family of wound closure products, offering a less painful and cost-effective alternative to traditional sutures and staples. The devices are designed for both personal use and healthcare professionals. In 2022, KitoTech entered a distribution agreement with Corza Medical to market microMend Pro in the US.

Knapsack is a Portland, Oregon–based enterprise software company providing infrastructure that connects design and code into a real-time system of record. Its digital production platform enables enterprise teams to build, govern, and deliver digital products at scale, integrating with tools like Figma and Git. The company raised $10 million in funding as of October 2025.