Hue Noir is a cosmetics company offering inclusive makeup products formulated for women of color, including foundations, lipsticks, and lip gloss. It is the only makeup brand in the US owned, formulated, and manufactured by a Black woman cosmetic chemist. Products are available online and through select retail stores.

Hydrolix is a real-time data platform that delivers sub-second analytics at global scale, addressing runaway costs, slow query performance, and fragile clusters. Founded in 2018, the platform enables real-time analytics across globally distributed data at internet scale, serving use cases ranging from servers and applications to large-scale observability workloads.

iGridSim is a utility-based technology company developing AI-powered solutions for autonomous power grids. The company provides advanced modeling, analytics, and grid integration services to enhance flexibility, resilience, and support a net-zero electric grid.

Inpria Corporation manufactures EUV metal oxide photoresists designed to enable semiconductor manufacturers to realize the full potential of extreme ultraviolet (EUV) lithography. Its inorganic photoresists offer superior etch resistance, allowing chipmakers to simplify the manufacturing process by eliminating extra layers. Inpria was acquired by JSR Corporation in 2021.

Instinct Science is an animal health technology company providing veterinary practice management software designed to help hospitals stay efficient, ensure patient safety, and capture every charge. Its platform supports veterinarians and hospital staff with workflow tools, and in January 2026 acquired ScribbleVet to advance intelligent veterinary practice management.

Invio is a Seattle-based startup that develops FDA-compliant, cloud-based software to automate clinical trial workflows, replacing traditional paper and manual monitoring processes. The company makes clinical trials safer and faster through enterprise software for remote and automated trial monitoring. Invio was selected as the first company out of Madrona Venture Labs' accelerator in 2018.

InVivo Biosystems is a biotechnology company headquartered in Eugene, Oregon, that delivers expertise and technology to accelerate therapeutic discovery. The company uses its proprietary platform to advance drug discovery for neurological, metabolic, and rare monogenic diseases.

IOTAS was a smart apartment technology platform founded in 2014 that integrated smart devices such as lighting, thermostats, and locks for multifamily properties. The company was acquired by ADT and its product line continued as ADT Multifamily, providing connected home solutions to apartment operators and residents.

Jama Software delivers an AI-powered engineering management platform through its flagship product Jama Connect, which combines requirements management and Live Traceability™ to help engineering teams in complex product development. The platform is widely used in industries requiring rigorous traceability and requirements tracking, such as aerospace, automotive, and medical devices.

JourneyTrack is an AI-forward decision intelligence platform for enterprise customer journey management. It helps CX, product, and operations teams map, track, and optimize customer experiences using tools like Journey AI, Persona AI, and Storytelling AI to reduce churn, accelerate growth, and prove CX ROI.

Kickplan is a turnkey monetization and billing platform for growth-stage SaaS companies, providing a full billing backend faster and with more flexibility than in-house builds. Headquartered in Pasadena, California, the company was founded in 2023 and has received venture funding.

KitoTech Medical is a medical device company that makes the microMend® family of wound closure products, offering a less painful and cost-effective alternative to traditional sutures and staples. The devices are designed for both personal use and healthcare professionals. In 2022, KitoTech entered a distribution agreement with Corza Medical to market microMend Pro in the US.

Knapsack is a Portland, Oregon–based enterprise software company providing infrastructure that connects design and code into a real-time system of record. Its digital production platform enables enterprise teams to build, govern, and deliver digital products at scale, integrating with tools like Figma and Git. The company raised $10 million in funding as of October 2025.

LegUp was a Seattle-based startup founded in 2019 that provided software to child care providers for scheduling, waitlist management, payment processing, and parent communications. The company raised $1.2 million in total funding before being acquired by Kinside in August 2022.

Locl is an AI-powered local SEO and listings management platform that enables businesses to manage and automate Google Business Profiles and directory listings across 50-plus directories from a single interface. The platform is designed to boost local visibility for single locations and enterprise-scale multi-location brands alike.

Lumen Learning is an education technology company that provides open educational resources (OER) and support services to higher education institutions. Its online course materials and tools are designed to enable more effective and affordable learning for college students, and the company has been named one of TIME's Top EdTech Companies in America.

Lumencor designs and manufactures solid-state light engines and illuminators for life science instrumentation, including fluorescence microscopes and cellular analysis systems. The company applies intelligent design to produce best-in-class photonics products, and has been recognized as a Top 10 Photonics Solutions Provider by Semiconductor Review Magazine.

Lytics was a customer data platform (CDP) startup founded in Portland, Oregon, that helped brands unify and activate customer data for personalized marketing. In January 2025, Lytics was acquired by Contentstack, an Austin-based digital experience platform company.