Knapsack is a Portland, Oregon–based enterprise software company providing infrastructure that connects design and code into a real-time system of record. Its digital production platform enables enterprise teams to build, govern, and deliver digital products at scale, integrating with tools like Figma and Git. The company raised $10 million in funding as of October 2025.

LegUp was a Seattle-based startup founded in 2019 that provided software to child care providers for scheduling, waitlist management, payment processing, and parent communications. The company raised $1.2 million in total funding before being acquired by Kinside in August 2022.

Locl is an AI-powered local SEO and listings management platform that enables businesses to manage and automate Google Business Profiles and directory listings across 50-plus directories from a single interface. The platform is designed to boost local visibility for single locations and enterprise-scale multi-location brands alike.

Lumen Learning is an education technology company that provides open educational resources (OER) and support services to higher education institutions. Its online course materials and tools are designed to enable more effective and affordable learning for college students, and the company has been named one of TIME's Top EdTech Companies in America.

Lumencor designs and manufactures solid-state light engines and illuminators for life science instrumentation, including fluorescence microscopes and cellular analysis systems. The company applies intelligent design to produce best-in-class photonics products, and has been recognized as a Top 10 Photonics Solutions Provider by Semiconductor Review Magazine.

Lytics was a customer data platform (CDP) startup founded in Portland, Oregon, that helped brands unify and activate customer data for personalized marketing. In January 2025, Lytics was acquired by Contentstack, an Austin-based digital experience platform company.

Madorra is a medical device company focused on women's health that has developed a therapeutic ultrasound device to treat vaginal atrophy in breast cancer survivors. The device increases vasodilation and blood flow to improve vaginal health and female sexual function, and originated from the Stanford Biodesign program.

Magnify.io is an AI-powered go-to-market platform focused on Customer Growth Automation (CGA), helping revenue teams turn customer signals into predictable growth. The platform combines data aggregation, AI analysis, and automation across the entire GTM stack to optimize and automate the post-sales customer lifecycle.

Magwire Inc. is a Portland-based nanotechnology company developing solutions to improve flexible displays in smartphones and other touch-screen devices. The company applies nanowire technology to advance next-generation flexible display performance.

Mass Ingenuity is a Portland, Oregon-based SaaS company focused on enterprise performance management (EPM) for government agencies. In April 2026, the company was acquired by Weaver, adding its EPM platform to Weaver's advisory and consulting services.

MAV Unlimited has developed a large-format, volumetric additive manufacturing system claimed to be up to 50x faster than the next fastest commercial 3D printer. The company is built on Cornell-licensed IP with an MIT residency, and aims to transform manufacturing speed and location flexibility.

medZERO gives employees on-demand access to healthcare funds to pay out-of-pocket healthcare expenses over time, with zero interest and zero fees. The platform serves employers and their employees by offering interest-free and fee-free financing for care expenses.

Megh Computing is a Portland, Oregon-based company that provides real-time, AI-based video analytics solutions deployable from edge to cloud. The company develops software tools designed for use with FPGAs and offers scalable intelligent video analytics with high-performing, low-latency AI acceleration.

Mickelberry Gardens is a women-owned certified B Corporation based in Portland, Oregon, founded by herbalist Madelyn and beekeeper Matt. The company offers a line of herbal wellness products inspired by honeybees, with a mission to provide healing and delicious products.

Minnow Technologies is a Seattle-based startup founded in 2017 that makes smart electronic food-delivery lockers called Pickup Pods for foodservice and multifamily residential settings. The company raised $3 million in a Series Seed round in 2021 and has deployed its contactless food lockers at properties across the US.

mpathic is a clinician-founded AI safety company dedicated to improving the quality and safety of human–AI conversations. It provides technology-enabled, expert-led human data and evaluation services—including red teaming and benchmarking—for frontier AI builders. The company works with thousands of mental health experts, doctors, and clinicians to keep humans safe in the AI era.

MustDeliver is a digital freight matching platform that connects independent truck drivers directly with shippers to book loads. The company also offers API integration for shippers and has raised $1.1 million in funding.

Myoaligner is a dental technology company offering an FDA-cleared patented system for the treatment of migraine headaches, TMJ disorders (TMJD), tension headaches, and restorative dentistry applications. The device provides a non-invasive solution for patients suffering from temporomandibular joint disorders and related conditions.